FISH OIL FOR ASTHMA

The January 2006 issue of the Journal Chest reported that supplementation with Fish Oil reduced the severity of exercise induced bronchoconstriction. In a randomized, double blind, crossover study, 16 asthmatic patients who suffer EIB were given 3.2 g/d of EPA and 2.0 g/d 20 of DHA. Eight of the patients in the study who were given the fish oil had a significant reduction in inflammation. The use of bronchodilators also decreased. Of interest is that the study was just three weeks duration. The power of nutrition is amazing; that the body can respond in such a shorttime will provide powerful encouragement and hope to anyone who suffers with Asthma. Here's the report:
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Chest. January 2006;129:39-49.) 2006 American College of Chest PhysiciansProtective Effect of Fish Oil Supplementation on Exercise-Induced Bronchoconstriction in Asthma*Timothy D. Mickleborough, PhD; Martin R. Lindley, PhD; Alina A. Ionescu, MDand Alyce D. Fly, PhD* From Human Performance and Exercise Biochemistry Laboratory (Drs.Mickleborough and Lindley), Department of Kinesiology, Indiana University, Bloomington, IN; Section of Respiratory Medicine and Communicable Diseases (Dr. Ionescu), University of Wales College of Medicine, University Hospital of Wales and Llandough Hospital, NHS Trust, Penarth, UK; and Department of Applied Health Science (Dr. Fly), Nutrition and Dietetics, Indiana University, Bloomington, IN. Correspondence to: Timothy D. Mickleborough, PhD, Department of Kinesiology, Indiana University, 1025 E Seventh St, HPER 112, Bloomington, IN 47401;
e-mail: tmickleb@indiana.edu

Background: Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties. Since EIB in asthma involves proinflammatory mediator release, it is feasible that fish oil supplementation may reduce the severity of EIB in asthmatic subjects.

Study objectives: To determine the efficacy of fish oil supplementation on severity of EIB in subjects with asthma.

Design: Randomized, double-blind, crossover study.

Setting: Lung function and exercise testing in a university research laboratory.

Patients and measurements: Sixteen asthmatic patients with documented EIB entered the study on their normal diet and then received either fish oil capsules containing 3.2 g of eicosapentaenoic acid and 2.0 g of docohexaenoic acid (fish oil diet, n =3D 8) or placebo capsules (placebo diet,n =3D 8) daily for 3 weeks. At the beginning of the study (normal diet) and at the end of each treatment phase, the following pre-exercise and postexercise measures were assessed: (1) pulmonary function; (2) induced sputum differential cell count percentage and proinflammatory eicosanoid metabolite(leukotriene C4 [LTC4]-leukotriene E4 [LTE4] and prostaglandin D2 [PGD2]) and cytokine (interleukin [IL]-1=DF and tumor necrosis factor [TNF]-{alpha}) concentrations; and (3) eicosanoid metabolites leukotriene B4 (LTB4) and leukotriene B5 (LTB5) generation from activated polymorphonuclear leukocytes(PMNLs).

Results: On the normal and placebo diet, subjects exhibited EIB. However, the fish oil diet improved pulmonary function to below the diagnostic EIB threshold, with a concurrent reduction in bronchodilator use. Induced sputum differential cell count percentage and concentrations of LTC4-LTE4,PGD2,IL-1=DF, and TNF-{alpha} were significantly reduced before and following exercise on the fish oil diet compared to the normal and placebo diets. There was a significant reduction in LTB4 and a significant increase in LTB5 generation from activated PMNLs on the fish oil diet compared to the normal and placebo diets.

Conclusion: Our data suggest that fish oil supplementation may represent a potentially beneficial nonpharmacologic intervention for asthmatic subjects with EIB.

If you would like further information on quality supplements including fish oil, click on the title of this Blog. For special pricing, please contact me at KarenVanSprange@usana.com.